Matthijs Constantijn Dorst, PhD.

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Neuroscientist in the Silberberg lab at the Karolinska Institutet in Stockholm, Sweden. Biker, geek, excessive zip-tie user. Basal ganglionist and patch-clamp electrophysiologist for my sins.

In my research I combine multi-cell ex vivo patch clamp electrophysiology with chemogenetics, optogenetics and pharmacological manipulation to investigate the neural microcircuits of the Striatum. Through my background in machine learning and experience in experimental neuroscience I aim to unravel the complex web of interactions between acetylcholine and dopamine.
My analysis tools are on , 3D printing designs on .

Publications:

Dorst, M.C., Tokarska, A., Zhou, M., Lee, K., Stagkourakis, S., Broberger, C., Masmanidis, S. and Silberberg, G. 2020. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature Communications, 11, 5113.

Hjorth, J., Kozlov, A.K., Carannante, I., Frost-Nylén, J., Lindroos, R., Johansson, Y., Tokarska, A., Dorst, M.C., Suryanarayana, S.M., Silberberg, G., Hellgren Kotaleski, J., and Grillner, S. 2020. The microcircuits of striatum in silico. PNAS, 202000671,

Papathanou, M., Creed, M., Dorst, M.C., Bimpisidis, Z., Dumas, S., Pettersson, H., Bellone, C., Silberberg, G., Lüscher, C. and Wallén-Mackenzie, Å., 2018. Targeting VGLUT2 in mature dopamine neurons decreases mesoaccumbal glutamatergic transmission and identifies a role for glutamate co-release in synaptic plasticity by increasing baseline AMPA/NMDA ratio. Frontiers in neural circuits, 12, p.64.

Lindroos, R., Dorst, M.C., Du, K., Filipović, M., Keller, D., Ketzef, M., Kozlov, A.K., Kumar, A., Lindahl, M., Nair, A.G. and Pérez-Fernández, J., 2018. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4. 2. Frontiers in neural circuits, 12, p.3.

Garas, F.N., Shah, R.S., Kormann, E., Doig, N.M., Vinciati, F., Nakamura, K.C., Dorst, M.C., Smith, Y., Magill, P.J. and Sharott, A., 2016. Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife, 5, p.e16088.
Last updated: 2020-10-09.